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Your Skin and Nails and Chemotherapy

The side effects of chemotherapy depend on the type of chemotherapy. It also depends on how much is given. You can anticipate and manage the side effects. It can help to minimize them and provide the best possible experience while receiving chemotherapy.

Side effects on the skin and nails

Your personal medical profile and diagnosis is different than anyone else. So is your reaction to treatment. You may have severe, mild, or no side effects at all. Talk with your cancer care team about possible side effects of treatment before the treatment begins.

Chemotherapy can affect both the skin and nails. It may cause these symptoms:


  • Sensitivity to the sun

  • Redness

  • Rash

  • Itchiness

  • Peeling

  • Dryness

  • Acne

  • Darkening


  • Darkness

  • Yellowing

  • Brittleness

  • Cracking

  • Vertical lines or ridges

Sometimes, chemotherapy given by IV (intravenous) causes the skin covering the vein to darken. This happens more often in people who have very dark skin. Cosmetics or makeup may be used to cover the darkened area, but it can take a lot of time if more than 1 vein is affected. After treatment ends, the darkened areas often fade over time.

Although some side effects can be self-managed, others need immediate medical attention. If you are getting IV medicine, report any burning or pain to your healthcare provider right away. Sometimes, IV medicines can leak out of the vein and possibly cause tissue damage. These symptoms need to be reported to your healthcare team immediately.

Other skin and nail symptoms may indicate an allergic reaction. Report these symptoms to your cancer care team right away or seek immediate medical attention if you develop the following:

  • Sudden or severe itching

  • Rash 

  • Hives

  • Wheezing

  • Trouble breathing

How can I manage skin and nail problems?

The following is recommended for reducing your skin and nail problems related to chemotherapy.


  • Keep your face clean and dry.

  • Talk with your healthcare team about the use of any over-the-counter medicated creams or soaps before using them.

Itching and dryness

  • Use warm water for showers or baths. Hot water can dry your skin more. Use a mild, moisturizing soap.

  • Pat skin dry instead of rubbing it.

  • Apply cream or lotion to your skin while it is still moist. Ask your healthcare team what moisturizers they recommend.

  • Shave less often or stop shaving if it irritates your skin.

  • Don't use products that contain alcohol or fragrance. They can irritate your skin.

Nail problems

  • Don't use nail-strengthening products as they may bother your skin and nails.

  • Keep nails clean and short.

  • Don't get manicures and pedicures.

  • Wear gloves when doing housework or working in the garden.

  • Call your healthcare provider if you notice redness, pain, or changes around the cuticles.

  • Don't wear tight shoes.

Sensitivity to the sun

  • Stay out of direct sunlight as much as possible, and especially between the peak hours of 10 a.m. and 4 p.m. when the sun's rays are the strongest. Even if you have dark skin, protect yourself from the sun.

  • Use a sunscreen lotion with an SPF of 15 or higher. Zinc oxide, sold over the counter, can block the sun's rays completely.

  • Use a lip balm with a high sun protection factor.

  • Wear long-sleeve cotton shirts, pants, and hats with a wide brim to prevent your skin and scalp from sunburn.

If you develop a rash or have sudden severe itching, call your healthcare provider. Ask your healthcare providers what other symptoms need an immediate call to the office. Try to remember that as difficult as skin and nail problems can be, most do go away after treatment.

Online Medical Reviewer: Amy Finke RN BSN
Online Medical Reviewer: Jessica Gotwals RN BSN MPH
Online Medical Reviewer: Todd Gersten MD
Date Last Reviewed: 7/1/2023
© 2000-2024 The StayWell Company, LLC. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.
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